Designing Molecular Glues on March 22, 2023 in Needham, United States
- Event Type: Conference
- Presentation: Digital
- Website URL: https://www.degradersandglues.com/designing-molecular-glues
- Contact E-mail: [email protected]
- Location: Needham, United States
- Venue: CII
- Date: March 22, 2023
- Organization: Cambridge Healthtech Institute
- Conference Tags: molecular biology protein interaction protein molecular modeling molecular imaging
Hetero-bifunctional protein degraders like proteolysis targeting chimeras (PROTACs) have found their way into the clinic by utilizing the body’s natural disposal system to tag and degrade unwanted proteins implicated in various diseases. These degraders are large molecules consisting of a E3 binding ligand and a ligand binding the target protein, coupled together by a linker. On the other hand, monovalent degraders or molecular glues consist of a single degrader molecule that attaches to both the E3 ligase and target protein and tend to be smaller and more drug-like. These glues have been discovered serendipitously in the past, however recently, there are efforts being made to try and design them more rationally. Cambridge Healthtech Institute’s inaugural virtual conference discusses some of these innovative design strategies and screening methods to discover and optimize molecular glues for therapeutic purposes. The conference features live talks given by experts and includes online discussions for active networking and idea-generation.
Coverage will include, but is not limited to:
Monovalent degraders versus hetero-bifunctional degraders like PROTACs
Strategies for rational design of molecular glues
Screening methods and cellular assays for glue discovery
Applications for molecular glues beyond protein degradation
Advances and challenges in developing molecular glues as therapeutics
Name: Cambridge Healthtech Institute
Website: https://www.healthtech.com/
Address: 250 First Avenue, Suite 300
Description | Price | Date |
---|---|---|
Special Early Bird | EUR 799.00 | Before November 18, 2022 |
Early | EUR 899.00 | Before January 13, 2023 |
Advanced | EUR 949.00 | Before February 25, 2023 |
Standard | EUR 999.00 | After February 25, 2023 |
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